Relationship of serum bisphenol A with diabetes in the Thai population, National Health Examination Survey IV, 2009

J Diabetes. 2015 Mar;7(2):240-9. doi: 10.1111/1753-0407.12159. Epub 2014 May 8.


Background: Epidemiological studies of the association between bisphenol A (BPA) exposure and diabetes have been inconsistent. The present study determined serum BPA concentrations in the Thai population and their association with hyperglycemia and diabetes.

Methods: In all, 2581 serum samples from the Thai National Health Examination Survey (2009) were used to determine BPA levels. Impaired fasting glucose (IFG) was defined as fasting plasma glucose ≥100 and <126 mg/dL. Diabetes was defined as a history of a physician's diagnosis or fasting plasma glucose ≥126 mg/dL. Multinomial logistic regression was used to examine the association of serum BPA with IFG and diabetes.

Results: Of 2581 samples tested, BPA was detected in 2135 samples (weighted percentage 78.1%), with a geometric mean concentration of 0.34 ng/mL BPA. Serum BPA levels were significantly higher among those with diabetes or IFG compared with normoglycemic individuals (0.52 and 0.38 vs 0.33 ng/mL, respectively; P < 0.001). After adjusting for potential confounders, compared with the first quartile (≤0.071 ng/mL), the overall adjusted odds ratios (OR) of serum BPA concentration in the third and fourth quartiles (0.319-0.745 and ≥0.746 ng/mL, respectively) for IFG were 1.72 (95% confidence interval [CI] 1.19, 2.49) and 1.23 (95% CI 0.80, 1.89), respectively; for diabetes, the adjusted OR were 1.88 (95% CI 1.18, 2.99) and 1.83 (95% CI 1.12, 2.95), respectively, with a slightly stronger association among men than in women.

Conclusions: Serum BPA concentrations were not associated with IFG, but were positively associated with diabetes in the Thai population. Further prospective studies are needed to confirm the relationship.

Keywords: bisphenol A; diabetes; endocrine disruptor; impaired fasting glucose; 关键词:双酚丙烷,糖尿病,内分泌干扰物,空腹葡萄糖受损.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Benzhydryl Compounds / blood*
  • Benzhydryl Compounds / therapeutic use
  • Blood Glucose / analysis*
  • China
  • Cross-Sectional Studies
  • Diabetes Mellitus / blood*
  • Diabetes Mellitus / drug therapy
  • Female
  • Follow-Up Studies
  • Free Radical Scavengers / blood*
  • Free Radical Scavengers / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Nutrition Surveys*
  • Phenols / blood*
  • Phenols / therapeutic use
  • Prognosis
  • Thailand
  • Young Adult


  • Benzhydryl Compounds
  • Blood Glucose
  • Free Radical Scavengers
  • Phenols
  • bisphenol A