Abstract
Tetralogy of Fallot and a complete atrioventricular septal defect are thought to arise by distinct mechanisms, yet their co-occurrence is a recognized association. Analysis of the prevalence of co-occurrence in Down syndrome suggests a common developmental basis. Trisomy 21 may perturb cardiac progenitor cells before they enter the heart tube.
Copyright © 2014 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Child, Preschool
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Down Syndrome / complications*
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Down Syndrome / physiopathology
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Heart Septal Defects
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Humans
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Infant
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Mitral Valve Insufficiency / complications*
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Mitral Valve Insufficiency / epidemiology
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Mitral Valve Insufficiency / physiopathology
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Tetralogy of Fallot / complications*
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Tetralogy of Fallot / epidemiology
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Tetralogy of Fallot / physiopathology
Supplementary concepts
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Complete atrioventricular septal defect