Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics

Curr Opin Pharmacol. 2014 Apr;15:7-15. doi: 10.1016/j.coph.2013.11.002. Epub 2013 Nov 26.

Abstract

Inward rectifier potassium (Kir) channels play fundamental roles in cardiac and renal function and may represent unexploited drug targets for cardiovascular diseases. However, the limited pharmacology of Kir channels has slowed progress toward exploring their integrative physiology and therapeutic potential. Here, we review recent progress toward developing the small-molecule pharmacology for Kir2.x, Kir4.1, and Kir7.1 and discuss common mechanistic themes that may help guide future Kir channel-directed drug discovery efforts.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Heart Diseases / drug therapy*
  • Heart Diseases / metabolism
  • Humans
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / metabolism
  • Models, Molecular
  • Potassium Channels, Inwardly Rectifying / agonists*
  • Potassium Channels, Inwardly Rectifying / antagonists & inhibitors*
  • Potassium Channels, Inwardly Rectifying / chemistry
  • Potassium Channels, Inwardly Rectifying / metabolism

Substances

  • Potassium Channels, Inwardly Rectifying