Epithelial sodium channel (ENaC) and the control of blood pressure

Curr Opin Pharmacol. 2014 Apr:15:33-46. doi: 10.1016/j.coph.2013.11.010. Epub 2013 Dec 12.


The amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. The activity of this channel is regulated by aldosterone and hormones involved in the maintenance of sodium balance, blood volume and blood pressure. In this review, we discuss recent advances in our understanding of ENaC function and regulation relevant to the control of sodium balance and blood pressure. The identification of novel drug targets should help in the development of the next generation of diuretics and of new therapies for the treatment of hypertension.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antihypertensive Agents / pharmacology*
  • Blood Pressure / drug effects
  • Blood Pressure / physiology*
  • Epithelial Sodium Channels / physiology*
  • Humans
  • Molecular Targeted Therapy


  • Antihypertensive Agents
  • Epithelial Sodium Channels