Review: higher vitamin D status and supplementation may be associated with risks

Eur J Dermatol. Jul-Aug 2014;24(4):428-34. doi: 10.1684/ejd.2014.2318.

Abstract

The prevalence of low vitamin D levels and associated risks has led to an increase in supplementation. However, a "U-shaped" relationship has been suggested between vitamin D status and adverse effects, with risks observed both in low and high levels. While risks associated with low levels of vitamin D have been extensively studied, the risks of higher levels of vitamin D have not been as widely circulated. We sought to describe key observed adverse risks with vitamin D supplementation and higher serum 25(OH)-D levels in healthy adult populations.

Keywords: epidemiology; vitamin D.

Publication types

  • Review

MeSH terms

  • Accidental Falls / statistics & numerical data
  • Asthma / epidemiology
  • Cardiovascular Diseases / epidemiology
  • Dietary Supplements / adverse effects*
  • Fractures, Bone / epidemiology
  • Humans
  • Hydroxycholecalciferols / blood
  • Mortality
  • Neoplasms / epidemiology
  • Neoplasms / mortality
  • Practice Guidelines as Topic
  • Prevalence
  • Risk Factors
  • Vitamin D / administration & dosage
  • Vitamin D / adverse effects*
  • Vitamin D / blood*
  • Vitamin D Deficiency / epidemiology
  • Vitamin D Deficiency / prevention & control
  • Vitamins / administration & dosage
  • Vitamins / adverse effects*
  • Vitamins / blood*

Substances

  • Hydroxycholecalciferols
  • Vitamins
  • Vitamin D