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Randomized Controlled Trial
, 37 (6), 1155-68

Psychosocial Predictors of Weight Regain in the Weight Loss Maintenance Trial

Randomized Controlled Trial

Psychosocial Predictors of Weight Regain in the Weight Loss Maintenance Trial

Phillip J Brantley et al. J Behav Med.


This study's purpose was to identify psychosocial predictors of weight loss maintenance in a multi-site clinical trial, following a group-based weight loss program. Participants (N = 1025) were predominately women (63%) and 38% were Black (mean age = 55.6 years; SD = 8.7). At 12 months, higher SF-36 mental health composite scores were associated with less weight regain (p < .01). For Black participants, an interaction existed between race and friends' encouragement for exercise, where higher exercise encouragement was related to more weight regain (p < .05). At 30 months, friends' encouragement for healthy eating was associated with more weight regain (p < .05), whereas higher SF-36 mental health composite scores were related to less weight regain (p < .0001). Perceived stress and select health-related quality of life indices were associated with weight regain; this relationship varied across gender, race, and treatment conditions. Temporal changes in these variables should be investigated for their impact on weight maintenance.

Conflict of interest statement

Conflict of interest: Phillip J. Brantley, Diana W. Stewart, Valerie H. Myers, Molly R. Matthews-Ewald, Jamy D. Ard, Janelle Coughlin, Carmen Samuel-Hodge, Lillian D. Lien, Christina M. Gullion, Jack F. Hollis, Laura P. Svetkey, and Victor J. Stevens declare that they have no conflict of interest. Gerald J. Jerome declares consultation for Healthways, Inc. as a potential conflict of interest.


Fig. 1
Fig. 1. Flowchart of randomization and follow-up
Fig. 2
Fig. 2. 2-way interaction of weight by friends' encouragement for exercise at 12 months
Fig. 3
Fig. 3. 2-way interactions between race and 3 SF-36 subscales a mental health, b, physical health, c vitality, at 30 months
Fig. 4
Fig. 4. 4-way interaction of race by gender by treatment by stress and post-hoc comparisons of treatment, at 30 months

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