Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 5, 30
eCollection

Computational Neuropsychiatry - Schizophrenia as a Cognitive Brain Network Disorder

Affiliations
Review

Computational Neuropsychiatry - Schizophrenia as a Cognitive Brain Network Disorder

Maria R Dauvermann et al. Front Psychiatry.

Abstract

Computational modeling of functional brain networks in fMRI data has advanced the understanding of higher cognitive function. It is hypothesized that functional networks mediating higher cognitive processes are disrupted in people with schizophrenia. In this article, we review studies that applied measures of functional and effective connectivity to fMRI data during cognitive tasks, in particular working memory fMRI studies. We provide a conceptual summary of the main findings in fMRI data and their relationship with neurotransmitter systems, which are known to be altered in individuals with schizophrenia. We consider possible developments in computational neuropsychiatry, which are likely to further our understanding of how key functional networks are altered in schizophrenia.

Keywords: cognition; computational neuropsychiatry; dopamine; dynamic causal modeling; fMRI; glutamate; neurotransmitter; schizophrenia.

Figures

Figure 1
Figure 1
Understanding of schizophrenia as a cognitive brain disorder – verbal/numeric “N-back” task. afMRI; bPET, positron emission tomography.
Figure 2
Figure 2
Understanding of schizophrenia as a cognitive brain disorder – spatial “N-back” task.
Figure 3
Figure 3
Understanding of schizophrenia as a cognitive brain network disorder – verbal/numeric “N-back” task.

Similar articles

See all similar articles

Cited by 7 PubMed Central articles

See all "Cited by" articles

References

    1. MacDonald AW, Schulz SC. What we know: findings that every theory of schizophrenia should explain. Schizophr Bull (2009) 35:493–50810.1093/schbul/sbp017 - DOI - PMC - PubMed
    1. Fusar-Poli P, Howes OD, Allen P, Broome M, Valli I, Asselin MC, et al. Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study. Arch Gen Psychiatry (2010) 67(7):683–9110.1001/archgenpsychiatry.2010.77 - DOI - PubMed
    1. Gold JM. Cognitive deficits as treatment targets in Schizophrenia. Schizophr Res (2004) 72(1):21–810.1016/j.schres.2004.09.008 - DOI - PubMed
    1. Seidman LJ, Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, et al. Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis. Arch Gen Psychiatry (2010) 67:578–8810.1001/archgenpsychiatry.2010.66 - DOI - PMC - PubMed
    1. Kim HS, Shin NY, Jang JH, Kim E, Shim G, Park HY, et al. Social cognition and neurocognition as predictors of conversion to psychosis in individuals at ultra-high risk. Schizophr Res (2011) 130:170–510.1016/j.schres.2011.04.023 - DOI - PubMed

LinkOut - more resources

Feedback