Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014;2014:760683.
doi: 10.1155/2014/760683. Epub 2014 Mar 4.

Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum Arvense (Field Horsetail) in Healthy Volunteers

Affiliations
Free PMC article

Randomized, Double-Blind Clinical Trial to Assess the Acute Diuretic Effect of Equisetum Arvense (Field Horsetail) in Healthy Volunteers

Danilo Maciel Carneiro et al. Evid Based Complement Alternat Med. .
Free PMC article

Abstract

In this double-blind, randomized clinical trial, 36 healthy male volunteers were randomly distributed into three groups (n = 12) that underwent a three-step treatment. For four consecutive days, we alternately administered a standardized dried extract of Equisetum arvense (EADE, 900 mg/day), placebo (corn starch, 900 mg/day), or hydrochlorothiazide (25 mg/day), separated by a 10-day washout period. Each volunteer served as his own control, and the groups' results were compared. We repeated the same evaluation after each stage of treatment to evaluate the safety of the drug. The diuretic effect of EADE was assessed by monitoring the volunteers' water balance over a 24 h period. The E. arvense extract produced a diuretic effect that was stronger than that of the negative control and was equivalent to that of hydrochlorothiazide without causing significant changes in the elimination of electrolytes. There was no significant increase in the urinary elimination of catabolites. Rare minor adverse events were reported. The clinical examinations and laboratory tests showed no changes before or after the experiment, suggesting that the drug is safe for acute use. Further research is needed to better clarify the mechanism of diuretic action and the other possible pharmacological actions of this phytomedicine.

Figures

Figure 1
Figure 1
Comparisons of the fluid balance between groups (n = 36/group). Groups: A = Equisetum arvense; B = hydrochlorothiazide; C = placebo. A versus C (P < 0.001). B versus C (P = 0.026). A versus B (P = 0.056).

Similar articles

See all similar articles

Cited by 3 articles

References

    1. Geavlete P, Multescu R, Geavlete B. Serenoa repens extract in the treatment of benign prostatic hyperplasia. Therapeutic Advances in Urology. 2011;3(4):193–198. - PMC - PubMed
    1. WHO. Traditional Medicine. World Health Organization; 2008.
    1. Brazil, National Institute of Industrial Property Rights. Laboratories increase the bets on the phytotherapeutic sector. 2011, http://susbrasil.net/2012/03/10/laboratorios-reforcam-apostas-no-segmento-fitoterapico/
    1. Blumenthal M, Goldberg A, Brickmann J. Herbal Medicine: Expanded Commission E Monographs. Boston, Mass, USA: American Botanical Council; 2000.
    1. Gupta PM, editor. 270 Ibero-American Medicinal Plants. Bogota, Colombia: Santafé Convênio Andres Bello, CYTED; 1995.

LinkOut - more resources

Feedback