Hepatocellular carcinoma in Wilson's disease. Case report and review of the literature

J Clin Gastroenterol. 1989 Apr;11(2):220-4. doi: 10.1097/00004836-198904000-00022.


A 33-year-old man with Wilson's disease developed hemoptysis and radiographic evidence of nodular pulmonary infiltrates. A premortem diagnosis of hepatocellular carcinoma was made on the basis of alpha-naphthylannidase stains of pulmonary tissue obtained by open lung biopsy. We review all previous cases of Wilson's disease with this unusual complication and discuss the role of copper in hepatic oncogenesis as well as the alpha-naphthylannidase stain for the diagnosis of hepatocellular carcinoma.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adult
  • Biopsy
  • Carcinoma, Hepatocellular / pathology*
  • Hepatolenticular Degeneration / pathology*
  • Humans
  • Liver Neoplasms / pathology*
  • Male
  • Staining and Labeling