In vitro uptake of apoptotic body mimicking phosphatidylserine-quantum dot micelles by monocytic cell line

Andrei Maiseyeu; Vaishali Bagalkot

doi:10.1186/1556-276X-9-176

In vitro uptake of apoptotic body mimicking phosphatidylserine-quantum dot micelles by monocytic cell line

Nanoscale Res Lett. 2014 Apr 11;9(1):176. doi: 10.1186/1556-276X-9-176. eCollection 2014.

Authors

Andrei Maiseyeu¹, Vaishali Bagalkot²

Affiliations

¹ Division of Cardiovascular Medicine, Department of Medicine, University of Maryland, Baltimore, 20 Penn St., HSFII, S012D, Baltimore, MD 21201, USA.
² Division of Cardiovascular Medicine, Department of Medicine, University of Maryland, Baltimore, 20 Penn St., HSFII, S012D, Baltimore, MD 21201, USA ; Department of Internal Medicine/Cardiology, University of Texas Health Science Center (UTHSC), 1881 East Road, South Campus Research Building 3, Center for Advanced Biomedical Imaging Research, 3SCR6.4610, Houston, TX 77054, USA.

Abstract

A new quantum dot (QD) PEGylated micelle laced with phosphatidylserine (PS) for specific scavenger receptor-mediated uptake by macrophages is reported. The size and surface chemistry of PS-QD micelles were characterized by standard methods and the effects of their physicochemical properties on specific targeting and uptake were comprehensively studied in a monocytic cell line (J774A.1).

Keywords: Macrophages; Micelles; Phosphatidylserine; Quantum dots.