Recurrent aphthous stomatitis and pain management with low-level laser therapy: a randomized controlled trial

Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 May;117(5):590-594. doi: 10.1016/j.oooo.2014.01.228. Epub 2014 Feb 6.


Objective: The aim of the study was to determine whether low-level laser therapy (LLLT) has an analgesic effect in patients with recurrent aphthous stomatitis (RAS).

Study design: A randomized single-blinded placebo-controlled trial was conducted with LLLT (wavelength, 809 nm; power, 60 mW; pulse frequency, 1800 Hz; duration, 80 seconds per treatment; dose, 6.3 J/cm(2)) in 40 patients with RAS. The intervention group was treated with LLLT on 3 occasions, with a 1-day interval. The control group was treated similarly, without any laser power. Pain perception (visual analog scale [VAS] rating) and patients' experience of eating, drinking, and brushing teeth was registered.

Results: VAS rating decreased (day 0 until day 2) from 84.7 to 31.5 (LLLT) and from 81.7 to 76.1 (placebo) (P < .0001). LLLT also relieved the difficulty of drinking, eating, and brushing teeth.

Conclusions: LLLT reduced the pain and the inconvenience of eating, drinking, and brushing teeth for patients with RAS, compared with placebo.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Low-Level Light Therapy*
  • Male
  • Pain Management
  • Pain Measurement
  • Recurrence
  • Single-Blind Method
  • Stomatitis, Aphthous / radiotherapy*
  • Surveys and Questionnaires
  • Sweden
  • Treatment Outcome