Beta cell imaging - a key tool in optimized diabetes prevention and treatment
- PMID: 24726483
- DOI: 10.1016/j.tem.2014.02.002
Beta cell imaging - a key tool in optimized diabetes prevention and treatment
Abstract
The prevalence of diabetes is 382 million worldwide, and is expected to rise to 592 million in 2035 (http://www.idf.org/diabetesatlas); 2.5-15% of national annual healthcare budgets are related to diabetes care, potentially increasing to 40% in high-prevalence countries. Beta cell dysfunction and death are central events in diabetes pathogenesis, but the natural history of beta cell loss remains unknown. Clinical imaging of beta cells will play a pivotal role in developing strategies for optimized diabetes prevention and treatment.
Keywords: diabetes; imaging; pancreatic beta cells; pancreatic islets.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Similar articles
-
Protection of pancreatic beta-cells: is it feasible?Nutr Metab Cardiovasc Dis. 2008 Jan;18(1):74-83. doi: 10.1016/j.numecd.2007.05.004. Nutr Metab Cardiovasc Dis. 2008. PMID: 18096375 Review.
-
Pancreatic β-cell dysfunction, expression of iNOS and the effect of phosphodiesterase inhibitors in human pancreatic islets of type 2 diabetes.Diabetes Obes Metab. 2012 Nov;14(11):1010-9. doi: 10.1111/j.1463-1326.2012.01632.x. Epub 2012 Jul 4. Diabetes Obes Metab. 2012. PMID: 22687049
-
Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus.Diabetes Res Clin Pract. 2011 Aug;93 Suppl 1:S60-5. doi: 10.1016/S0168-8227(11)70015-8. Diabetes Res Clin Pract. 2011. PMID: 21864753 Review.
-
Minimal model: perspective from 2005.Horm Res. 2005;64 Suppl 3:8-15. doi: 10.1159/000089312. Epub 2006 Jan 20. Horm Res. 2005. PMID: 16439839 Review.
-
Beta-cell function and mass in type 2 diabetes.Dan Med Bull. 2009 Aug;56(3):153-64. Dan Med Bull. 2009. PMID: 19728971
Cited by
-
Lower insulin level is associated with sarcopenia in community-dwelling frail and non-frail older adults.Front Med (Lausanne). 2022 Nov 22;9:971622. doi: 10.3389/fmed.2022.971622. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36482911 Free PMC article.
-
Clinical and scientific value in the pursuit of quantification of beta cells in the pancreas by PET imaging.Diabetologia. 2018 Dec;61(12):2671-2673. doi: 10.1007/s00125-018-4718-8. Epub 2018 Aug 22. Diabetologia. 2018. PMID: 30136144 Free PMC article. No abstract available.
-
Whole organ and islet of Langerhans dosimetry for calculation of absorbed doses resulting from imaging with radiolabeled exendin.Sci Rep. 2017 Jan 9;7:39800. doi: 10.1038/srep39800. Sci Rep. 2017. PMID: 28067253 Free PMC article.
-
Imaging of Human Insulin Secreting Cells with Gd-DOTA-P88, a Paramagnetic Contrast Agent Targeting the Beta Cell Biomarker FXYD2γa.Molecules. 2018 Aug 21;23(9):2100. doi: 10.3390/molecules23092100. Molecules. 2018. PMID: 30134599 Free PMC article.
-
Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes.Diabetes. 2017 Aug;66(8):2163-2174. doi: 10.2337/db16-1285. Epub 2017 May 17. Diabetes. 2017. PMID: 28515126 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
