Acute-onset chronic inflammatory demyelinating polyneuropathy with focal segmental glomerulosclerosis

J Neurol Sci. 2014 Jun 15;341(1-2):139-43. doi: 10.1016/j.jns.2014.03.040. Epub 2014 Mar 29.


Inflammatory neuropathies have been reported to occur in association with nephrotic syndrome. Their underlying immuno-pathogenic mechanisms remain unknown. A 50-year-old woman concurrently presented with acute-onset chronic inflammatory demyelinating polyneuropathy and nephrotic syndrome secondary to focal segmental glomerulosclerosis. Both neuropathy and proteinuria improved after plasma exchange and steroids. Literature review of cases of concurrent inflammatory neuropathies and nephrotic syndrome revealed similar neuro-renal presentations. This neuro-renal condition may be mediated by autoantibodies targeting myelin and podocytes.

Keywords: Autoimmune disease; Chronic inflammatory demyelinating polyneuropathy; Focal segmental glomerulosclerosis; Guillain–Barré syndrome; Nephrotic syndrome; Peripheral neuropathy.

Publication types

  • Case Reports

MeSH terms

  • Electric Stimulation
  • Female
  • Glomerulosclerosis, Focal Segmental / complications*
  • Glomerulosclerosis, Focal Segmental / pathology
  • Humans
  • Middle Aged
  • Neural Conduction / physiology
  • Peripheral Nerves / physiopathology
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / complications*
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / pathology
  • Reaction Time / physiology
  • Time Factors