The outcome of ipsilateral hemihepatectomy in mucin-producing bile duct tumors

PLoS One. 2014 Apr 11;9(4):e92010. doi: 10.1371/journal.pone.0092010. eCollection 2014.


Background: Mucin-producing bile duct tumors (MPBTs) are unusual, and we present our experience with nine surgically proven cases.

Methods: Between November 2002 and November 2012, 9 patients with surgically proven MPBTs (including history of relevant hepatobiliary surgery in 6 patients) were encountered. Their clinical, imaging, and surgical findings were reviewed.

Results: The most common symptom is intermittent jaundice, which occurs in seven patients. The diagnostic specificity was 77.8% by preoperative Magnetic Resonance Cholangiopancreatography (MRCP). All the patients underwent ipsilateral hemihepatectomy or remnant hemihepatectomy, accompanied caudate lobectomy in one case and concomitant Roux-en-Y choledochojejunostomy in four cases. Postoperative course was uneventful. One patient, who had intra-abdominal recurrence 59 months after surgery, was received reoperation without recurrence at the last follow-up. The remaining eight patients were alive without disease recurrence.

Conclusion: Based on our follow up of 9 cases that were surgically treated for MPBTs, we conclude that ipsilateral hemihepatectomy is a safe surgical procedure with an observed recurrence risk of 11.1% and all long-term survival.

MeSH terms

  • Aged
  • Bile Duct Neoplasms / metabolism*
  • Bile Duct Neoplasms / surgery*
  • Female
  • Hepatectomy / adverse effects
  • Hepatectomy / methods*
  • Humans
  • Male
  • Middle Aged
  • Mucins / metabolism*
  • Neoplasm Recurrence, Local / metabolism*
  • Neoplasm Recurrence, Local / surgery*
  • Retrospective Studies


  • Mucins

Grants and funding

No current external funding sources for this study.