Volitional modulation of optically recorded calcium signals during neuroprosthetic learning

Nat Neurosci. 2014 Jun;17(6):807-809. doi: 10.1038/nn.3712. Epub 2014 Apr 13.


Brain-machine interfaces are not only promising for neurological applications, but also powerful for investigating neuronal ensemble dynamics during learning. We trained mice to operantly control an auditory cursor using spike-related calcium signals recorded with two-photon imaging in motor and somatosensory cortex. Mice rapidly learned to modulate activity in layer 2/3 neurons, evident both across and within sessions. Learning was accompanied by modifications of firing correlations in spatially localized networks at fine scales.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials / physiology
  • Animals
  • Brain-Computer Interfaces*
  • Calcium Signaling / physiology*
  • Cerebral Cortex / physiology*
  • Learning / physiology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Microscopy, Fluorescence, Multiphoton* / methods
  • Volition / physiology*