Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31

Nat Genet. 2014 May;46(5):498-502. doi: 10.1038/ng.2957. Epub 2014 Apr 13.

Abstract

Osteoarthritis is the most common form of arthritis and is a major cause of pain and disability in the elderly. To search for sequence variants that confer risk of osteoarthritis of the hand, we carried out a genome-wide association study (GWAS) in subjects with severe hand osteoarthritis, using variants identified through the whole-genome sequencing of 2,230 Icelanders. We found two significantly associated loci in the Icelandic discovery set: at 15q22 (frequency of 50.7%, odds ratio (OR) = 1.51, P = 3.99 × 10(-10)) in the ALDH1A2 gene and at 1p31 (frequency of 0.02%, OR = 50.6, P = 9.8 × 10(-10)). Among the carriers of the variant at 1p31 is a family with several members in whom the risk allele segregates with osteoarthritis. The variants within the ALDH1A2 gene were confirmed in replication sets from The Netherlands and the UK, yielding an overall association of OR = 1.46 and P = 1.1 × 10(-11) (rs3204689).

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Dehydrogenase 1
  • Base Sequence
  • Cartilage / metabolism
  • Chromosomes, Human, Pair 1 / genetics*
  • Computational Biology
  • Gene Expression Profiling
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • Genetic Variation*
  • Genotype
  • Hand / pathology*
  • Humans
  • Iceland
  • Molecular Sequence Data
  • Netherlands
  • Osteoarthritis / genetics*
  • Osteoarthritis / pathology
  • Retinal Dehydrogenase / genetics*
  • Sequence Analysis, DNA
  • United Kingdom

Substances

  • Aldehyde Dehydrogenase 1
  • ALDH1A2 protein, human
  • Retinal Dehydrogenase

Associated data

  • GEO/GPL3991
  • GEO/GSE7965