Crosstalk between fibroblasts and inflammatory cells

Cardiovasc Res. 2014 May 1;102(2):258-69. doi: 10.1093/cvr/cvu062. Epub 2014 Apr 11.


Fibroblasts, which are traditionally recognized as a quiescent cell responsible for extracellular matrix production, are more and more appreciated as an active key player of the immune system. This review describes how fibroblasts and immune cells reciprocally influence the pathogenesis of fibrosis. An overview is given how fibroblasts are triggered by components of the innate and adaptive immunity on the one hand and how fibroblasts modulate immune cell behaviour via conditioning the cellular and cytokine microenvironment on the other hand. Finally, latest insights into the role of cardiac fibroblasts in the orchestration of inflammatory cell infiltration in the heart, and their impact on heart failure, are outlined.

Keywords: Fibroblast; Heart failure; Innate and adaptive immune response; Myofibroblast.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity / immunology
  • Animals
  • Cytokines / immunology
  • Cytokines / metabolism
  • Fibroblasts / metabolism*
  • Fibroblasts / pathology
  • Heart Failure / immunology
  • Heart Failure / metabolism
  • Humans
  • Immune System / immunology
  • Immune System / metabolism*
  • Inflammation / immunology
  • Inflammation / metabolism*


  • Cytokines