Doxorubicin nanoconjugates

J Nanosci Nanotechnol. 2014 Jan;14(1):892-904. doi: 10.1166/jnn.2014.8765.

Abstract

Doxorubicin is one of the most widely administered drugs for treatment of cancer. The shortcomings commonly encountered with this drug are severe cardiotoxicity, narrow therapeutic indices, and the development of multiple drug resistance. Hence, several nanoparticulate drug delivery systems have been designed to overcome these limitations and to improvise the overall therapeutic efficacy of doxorubicin. This review outlines the doxorubicin delivery systems, viz., metals and metal oxide nanoparticles, carbon nanotubes, liposomes, nanoparticles of solid lipid materials, lipid microemulsions, polymer-based nanoparticles, protein-attached nanoparticles, polysaccharide nanoparticles, functional polymers, and nanoparticles of virus.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / chemistry
  • Diffusion
  • Doxorubicin / administration & dosage*
  • Doxorubicin / chemistry*
  • Humans
  • Nanocapsules / chemistry*
  • Nanocapsules / ultrastructure*
  • Neoplasms / drug therapy*
  • Particle Size
  • Surface Properties

Substances

  • Antineoplastic Agents
  • Nanocapsules
  • Doxorubicin