Aerobic plus resistance training was more effective in improving the visceral adiposity, metabolic profile and inflammatory markers than aerobic training in obese adolescents

J Sports Sci. 2014;32(15):1435-45. doi: 10.1080/02640414.2014.900692. Epub 2014 Apr 14.


The purpose of this study was to determine whether aerobic plus resistance training (AT + RT) is more effective than aerobic training (AT) at reducing inflammatory markers and cardiovascular risk in obese adolescents. A total of 139 obese adolescents were enrolled, aged 15-19 years, body mass index (BMI) ≥ 95th percentile and participated in 1 year of interdisciplinary intervention. They were randomised into two groups: AT (n = 55), AT + RT (n = 61). Blood samples were collected to analyse glycaemia, insulin, the lipid profile, leptin and adiponectin concentrations. Insulin resistance was measured by homeostasis model assessment of insulin resistance index (HOMA-IR). The AT + RT group showed better results with regard to decreased body fat mass, low-density lipoprotein concentration (LDL-c) levels, subcutaneous and visceral fat and increased body lean mass. Indeed, a reduction of hyperleptinaemia and an increase in adiponectin concentrations, promoting an improvement in the leptin/adiponectin ratio, was observed. Important clinical parameters were improved in both types of exercise; however, AT + RT was more effective in improving the visceral adiposity, metabolic profile and inflammatory markers than AT alone, suggesting clinical applications for the control of intra-abdominal obesity and cardiovascular risk in the paediatric population.

Keywords: adolescents; exercise; obesity; visceral fat.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdominal Fat / metabolism
  • Adiponectin / blood
  • Adiposity
  • Adolescent
  • Biomarkers / blood
  • Body Fluid Compartments / metabolism
  • Body Mass Index
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control*
  • Cholesterol, LDL / blood
  • Exercise*
  • Humans
  • Inflammation / blood
  • Inflammation / etiology
  • Inflammation / prevention & control*
  • Intra-Abdominal Fat / metabolism*
  • Leptin / blood
  • Obesity, Abdominal / blood
  • Obesity, Abdominal / metabolism
  • Obesity, Abdominal / therapy*
  • Pediatric Obesity / blood
  • Pediatric Obesity / complications
  • Pediatric Obesity / metabolism
  • Pediatric Obesity / therapy*
  • Resistance Training*
  • Subcutaneous Fat / metabolism
  • Young Adult


  • Adiponectin
  • Biomarkers
  • Cholesterol, LDL
  • Leptin