Effects of soybean oligosaccharides on antioxidant enzyme activities and insulin resistance in pregnant women with gestational diabetes mellitus

Food Chem. 2014 Sep 1:158:429-32. doi: 10.1016/j.foodchem.2014.02.106. Epub 2014 Mar 6.

Abstract

The effects of soybean oligosaccharides (SBOS) on antioxidant enzyme activities and insulin resistance in pregnant women with gestational diabetes mellitus (GDM) were investigated. Ninety-seven pregnant women with GDM were randomly divided into two groups, the control group (51 cases) and the SBOS group (46 cases). Before the group separation, the blood sugar level in patients was maintained stable by regular diet and insulin treatment. The control group was continued with the insulin treatment, while the SBOS group was treated with the combination of insulin and SBOS. Results showed that SBOS were able to reduce oxidative stress and alleviate insulin resistance in pregnant women with GDM, which indicates that SBOS may play an important role in the control of GDM complications.

Keywords: Antioxidant enzyme; Gestational diabetes mellitus; Insulin resistance; Soybean oligosaccharides.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antioxidants / administration & dosage
  • Antioxidants / chemistry
  • Diabetes, Gestational / blood
  • Diabetes, Gestational / diet therapy*
  • Diabetes, Gestational / enzymology
  • Female
  • Glycine max / chemistry*
  • Humans
  • Insulin / blood
  • Insulin Resistance*
  • Oligosaccharides / administration & dosage*
  • Oligosaccharides / chemistry
  • Pregnancy

Substances

  • Antioxidants
  • Insulin
  • Oligosaccharides