Hippocampal perivascular spaces are related to aging and blood pressure but not to cognition

Neurobiol Aging. 2014 Sep;35(9):2118-25. doi: 10.1016/j.neurobiolaging.2014.03.021. Epub 2014 Mar 22.


The risk factors of hippocampal dilated perivascular spaces (H-dPVS), their radiological relevance and their impact on cognitive performance remain under investigation. These aspects were evaluated in 1818 stroke- and dementia-free participants enrolled in the 3C-Dijon MRI study, using logistic regression, multiple linear regression, and Cox models. At study entry, the load of H-dPVS was found strongly associated with age and hypertension (degree 2 vs. degree 0: odds ratio: 1.16; 95% confidence interval: 1.02-1.33 and odds ratio: 1.98; 95% confidence interval: 1.39-2.81, respectively) and positively related to the presence of lacunar infarcts, white-matter hyperintensities volume, and hippocampal volume (p ≤ 0.024). Load of H-dPVS was not related to baseline cognitive performance (p > 0.05). Cox regression modeling did not show a significant relationship between the load of H-dPVS and incident dementia risk (p > 0.05). The present results support that both aging and blood pressure do play a key role in the development of H-dPVS in the older population. In contrast with the dilated perivascular spaces located in white matter or basal ganglia, the load of H-dPVS does not appear associated with occurrence of dementia.

Keywords: Cognition; Hippocampal dilated perivascular spaces; MRI; Risk factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / pathology*
  • Blood Pressure / physiology*
  • Cognition
  • Cohort Studies
  • Dilatation, Pathologic
  • Female
  • Hippocampus / pathology*
  • Humans
  • Hypertension / pathology*
  • Hypertension / physiopathology
  • Logistic Models
  • Magnetic Resonance Imaging / methods
  • Male
  • Proportional Hazards Models
  • Risk Factors