TMEM106B influences volume of left-sided temporal lobe and interhemispheric structures in the general population

Biol Psychiatry. 2014 Sep 15;76(6):503-8. doi: 10.1016/j.biopsych.2014.03.006. Epub 2014 Mar 14.


Background: Frontotemporal lobar degeneration is a neurodegenerative disease characterized by brain atrophy of the frontal and anterior temporal lobes. The associated frontotemporal dementia syndromes are clinically heterogeneous, and the pattern of affected cortical regions varies among subtypes. The TMEM106B rs1990622 polymorphism is associated with frontotemporal lobar degeneration, but little is known about how it affects the brain.

Methods: We investigated the rs1990622 polymorphism in relation to regional brain volumes to identify potential structures through which TMEM106B confers risk for frontotemporal lobar degeneration. In 4413 nondemented and stroke-free participants from the population-based Rotterdam Study, 150 cortical brain structures and 6 commissural regions were segmented from magnetic resonance imaging.

Results: A distinct pattern of association was found between rs1990622 and gray matter volume of left-sided temporal brain regions important for language processing, including the superior temporal gyrus (β=-88.8 μL per risk allele, p=7.64×10(-5)), which contains Wernicke's area. The risk allele was also associated with a smaller anterior commissure cross-sectional area (β=-.167 mm2 per risk allele, p=4.90×10(-5)) and posterior part of the corpus callosum (β=-15.3 μL per risk allele, p=1.23×10(-5)), both of which contain temporal lobe commissural tracts.

Conclusions: The asymmetric, predominantly left-sided involvement suggests an effect of TMEM106B on functions lateralized to the dominant hemisphere, such as language. These results show that, in nondemented persons, TMEM106B influences the volume of temporal brain regions that are important for language processing.

Keywords: Brain volumetry; commissural tracts; frontotemporal lobar degeneration; genetics; magnetic resonance imaging; population-based.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Brain / anatomy & histology*
  • Female
  • Frontotemporal Dementia / genetics
  • Functional Laterality / genetics
  • Genetic Predisposition to Disease
  • Gray Matter / anatomy & histology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Membrane Proteins / genetics*
  • Middle Aged
  • Nerve Tissue Proteins / genetics*
  • Polymorphism, Genetic
  • Risk Factors
  • Temporal Lobe / anatomy & histology*


  • Membrane Proteins
  • Nerve Tissue Proteins
  • TMEM106B protein, human