Emerging inhalation aerosol devices and strategies: where are we headed?

Adv Drug Deliv Rev. 2014 Aug;75:3-17. doi: 10.1016/j.addr.2014.03.006. Epub 2014 Apr 13.


Novel inhaled therapeutics including antibiotics, vaccines and anti-hypertensives, have led to innovations in designing suitable delivery systems. These emerging design technologies are in urgent demand to ensure high aerosolisation performance, consistent efficacy and satisfactory patient adherence. Recent vibrating-mesh and software technologies have resulted in nebulisers that have remarkably accurate dosing and portability. Alternatively, dry powder inhalers (DPIs) have become highly favourable for delivering high-dose and single-dose drugs with the aid of advanced particle engineering. In contrast, innovations are needed to overcome the technical constrains in drug-propellant incompatibility and delivering high-dose drugs with pressurised metered dose inhalers (pMDIs). This review discusses recent and emerging trends in pulmonary drug delivery systems.

Keywords: Computational modelling; Dry powder inhaler; Inhalation therapy; Nebuliser; Particle engineering; Patient adherence; Pressurised metered dose inhaler; Pulmonary drug delivery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aerosols
  • Drug Delivery Systems
  • Humans
  • Lung Diseases / drug therapy
  • Nebulizers and Vaporizers*
  • Respiratory System Agents / administration & dosage


  • Aerosols
  • Respiratory System Agents