Computer-based simulation is increasingly used in medical education for training, assessment, credentialing, and practice. Compared to medical specialties such as anesthesiology and general surgery, the adoption of simulation for neurointerventional training has been slow. This may be due to the limited number of neurointerventional simulators available and the lack of research assessing their validity and training capability. The objective of this study was to assess the realism, validity, and training capability of computer-based simulation for diagnostic cerebral angiography using a commercially available simulator called the ANGIO Mentor Express.