Effects of the Chinese herbal medicine "saiboku-to" on histamine release from and the degranulation of mouse peritoneal mast cells induced by compound 48/80

J Ethnopharmacol. 1988 Dec;24(2-3):303-9. doi: 10.1016/0378-8741(88)90159-6.

Abstract

The herbal medicine "Saiboku-to" (ST) has been used for the treatment of bronchial asthma. ST was found to inhibit histamine release from and the degranulation of mouse peritoneal mast cells induced by compound 48/80. Its inhibitory effects were concentration-related and somewhat weaker than disodium cromoglycate, a known inhibitor of histamine release and mast cell degranulation. From these results, ST could appear to be useful in the treatment of Type I allergic reactions.

MeSH terms

  • Animals
  • Asthma / drug therapy
  • Drugs, Chinese Herbal / pharmacology*
  • Histamine Release / drug effects*
  • Male
  • Mast Cells / drug effects*
  • Mast Cells / metabolism
  • Mast Cells / ultrastructure
  • Mice
  • Microscopy, Electron
  • Peritoneal Cavity
  • p-Methoxy-N-methylphenethylamine

Substances

  • Drugs, Chinese Herbal
  • p-Methoxy-N-methylphenethylamine