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. 2014 Oct 9;371(15):1418-25.
doi: 10.1056/NEJMoa1404505. Epub 2014 Apr 16.

Emergence of Zaire Ebola Virus Disease in Guinea

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Emergence of Zaire Ebola Virus Disease in Guinea

Sylvain Baize et al. N Engl J Med. .
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Abstract

In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known EBOV strains from the Democratic Republic of Congo and Gabon. Epidemiologic investigation linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December 2013. This study demonstrates the emergence of a new EBOV strain in Guinea.

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