Pelvic mature cystic teratoma with neuroendocrine carcinoma: report of a rare association and review of literature

Indian J Pathol Microbiol. 2014 Jan-Mar;57(1):113-5. doi: 10.4103/0377-4929.130916.


Extra-gonadal malignant transformation of teratoma is rare and there are only a few reports available citing malignancy arising in the non-germ cell components. We hereby report a case of a 35-year-old female, who presented with lower backache with a radiologically identifiable mass lesion in the pre-sacral region. Clinical and radiological findings suggested the possibility of a cystic teratoma. Histopathological examination and relevant immunohistochemical tests detected a mature cystic teratoma with features of a grade 2 neuroendocrine tumor in it. Like the index case, most of the previously reported cases of teratoma with malignant transformation of the somatic components were found in extra-gonadal site. This case is being reported to emphasize that any extra-gonadal mass in reproductive age group, even if it appears radiologically and per-operatively benign, must be subjected to histopathological examination to rule out possibility of malignant transformation of the germ cell or non-germ cell components.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Biomarkers, Tumor / analysis
  • Carcinoma, Neuroendocrine / complications*
  • Carcinoma, Neuroendocrine / diagnosis*
  • Carcinoma, Neuroendocrine / pathology
  • Female
  • Histocytochemistry
  • Humans
  • Immunohistochemistry
  • Keratins / analysis
  • Ki-67 Antigen / analysis
  • Microscopy
  • Pelvic Neoplasms / diagnosis*
  • Pelvic Neoplasms / pathology*
  • Radiography, Abdominal
  • Synaptophysin / analysis
  • Teratoma / complications*
  • Teratoma / diagnosis*
  • Teratoma / pathology
  • Tomography, X-Ray Computed


  • Biomarkers, Tumor
  • Ki-67 Antigen
  • Synaptophysin
  • Keratins