Characterizing the relationship between free drug samples and prescription patterns for acne vulgaris and rosacea

JAMA Dermatol. 2014 May;150(5):487-93. doi: 10.1001/jamadermatol.2013.9715.


Importance: Describing the relationship between the availability of free prescription drug samples and dermatologists' prescribing patterns on a national scale can help inform policy guidelines on the use of free samples in a physician's office.

Objectives: To investigate the relationships between free drug samples and dermatologists' local and national prescribing patterns and between the availability of free drug samples and prescription costs.

Design, setting, and participants: Cross-sectional study investigating prescribing practices for acne, a common dermatologic condition for which free samples are often available. The settings were, first, the offices of nationally representative dermatologists from the National Disease and Therapeutic Index (an IMS Health Incorporated database) and, second, an academic medical center clinic without samples. Participants were ambulatory patients who received a prescription from a dermatologist for a primary initial diagnosis of acne vulgaris or rosacea in 2010.

Main outcomes and measures: National trends in dermatologist prescribing patterns, the degree of correlation between the availability of free samples and the prescribing of brand-name medications, and the mean cost of acne medications prescribed per office visit nationally and at an academic medical center without samples.

Results: On a national level, the provision of samples with a prescription by dermatologists has been increasing over time, and this increase is correlated (r = 0.92) with the use of the branded generic drugs promoted by these samples. Branded and branded generic drugs comprised most of the prescriptions written nationally (79%), while they represented only 17% at an academic medical center clinic without samples. Because of the increased use of branded and branded generic drugs, the national mean total retail cost of prescriptions at an office visit for acne was conservatively estimated to be 2 times higher (approximately $465 nationally vs $200 at an academic medical center without samples).

Conclusions and relevance: Free drug samples can alter the prescribing habits of physicians away from the use of less expensive generic medications. The benefits of free samples in dermatology must be weighed against potential negative effects on prescribing behavior and prescription costs.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acne Vulgaris / diagnosis
  • Acne Vulgaris / drug therapy*
  • Cost Savings
  • Cross-Sectional Studies
  • Databases, Factual
  • Dermatologic Agents / economics
  • Dermatologic Agents / therapeutic use
  • Dermatology / methods
  • Drug Industry / economics
  • Drug Industry / trends*
  • Drug Utilization / economics
  • Drug Utilization / trends*
  • Female
  • Humans
  • Male
  • Marketing / economics
  • Marketing / trends
  • Practice Patterns, Physicians' / economics
  • Practice Patterns, Physicians' / trends*
  • Prescription Drugs / administration & dosage*
  • Rosacea / diagnosis
  • Rosacea / drug therapy*
  • United States


  • Dermatologic Agents
  • Prescription Drugs