Docetaxel-induced palmoplantar erythrodysesthesia syndrome and long-lasting multiple nail changes

Indian J Pharmacol. 2014 Mar-Apr;46(2):225-7. doi: 10.4103/0253-7613.129326.


Palmoplantar erythrodysesthesia syndrome (PPES) and nail changes are common presentations of cutaneous toxicity of docetaxel chemotherapy, which deteriorate the quality of life of patients. Herein, we describe a female patient who developed PPES and multiple nail changes due to docetaxel treatment for infiltrative ductal carcinoma. Cold application and elevation of extremities during docetaxel infusion, potent topical steroids and oral pyridoxine increased the tolerance to chemotherapy and provided regression of painful cutaneous lesions without cessation of the treatment.

Keywords: Chemotherapy; docetaxel; nail; palmoplantar erythrodysesthesia syndrome.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / pathology
  • Carcinoma, Ductal, Breast / drug therapy
  • Carcinoma, Ductal, Breast / pathology
  • Docetaxel
  • Female
  • Hand-Foot Syndrome / diagnosis
  • Hand-Foot Syndrome / etiology*
  • Humans
  • Middle Aged
  • Onycholysis / chemically induced*
  • Onycholysis / diagnosis
  • Taxoids / administration & dosage
  • Taxoids / adverse effects*
  • Taxoids / therapeutic use
  • Time Factors


  • Antineoplastic Agents
  • Taxoids
  • Docetaxel