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Review
, 2014, 476068

Porphyromonas Gingivalis: Major Periodontopathic Pathogen Overview

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Review

Porphyromonas Gingivalis: Major Periodontopathic Pathogen Overview

Jaroslav Mysak et al. J Immunol Res.

Abstract

Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. This anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. The purpose of this review is to provide an overview of one of the main periodontal pathogens-Porphyromonas gingivalis. This bacterium, along with Treponema denticola and Tannerella forsythia, constitute the "red complex," a prototype polybacterial pathogenic consortium in periodontitis. This review outlines Porphyromonas gingivalis structure, its metabolism, its ability to colonize the epithelial cells, and its influence upon the host immunity.

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References

    1. Bodet C, Chandad F, Grenier D. Pathogenic potential of Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, the red bacterial complex associated with periodontitis. Pathologie Biologie. 2007;55(3-4):154–162. - PubMed
    1. Yilmaz Ö. The chronicles of Porphyromonas gingivalise: the microbium, the human oral epithelium and their interplay. Microbiology. 2008;154(10):2897–2903. - PMC - PubMed
    1. Kinane DF, Galicia JC, Gorr S-U, Stathopoulou PG, Benakanakere M. P. gingivalis interactions with epithelial cells. Frontiers in Bioscience. 2008;13(3):966–984. - PubMed
    1. Bostanci N, Belibasakis GN. Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen. FEMS Microbiology Letters. 2012;333(1):1–9. - PubMed
    1. Bélanger M, Rodrigues PH, Dunn WA, Jr., Progulske-Fox A. Autophagy: a highway for Porphyromonas gingivalis in endothelial cells. Autophagy. 2006;2(3):165–170. - PubMed

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