Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 2014, 476068

Porphyromonas Gingivalis: Major Periodontopathic Pathogen Overview


Porphyromonas Gingivalis: Major Periodontopathic Pathogen Overview

Jaroslav Mysak et al. J Immunol Res.


Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. This anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. The purpose of this review is to provide an overview of one of the main periodontal pathogens-Porphyromonas gingivalis. This bacterium, along with Treponema denticola and Tannerella forsythia, constitute the "red complex," a prototype polybacterial pathogenic consortium in periodontitis. This review outlines Porphyromonas gingivalis structure, its metabolism, its ability to colonize the epithelial cells, and its influence upon the host immunity.

Similar articles

See all similar articles

Cited by 54 PubMed Central articles

See all "Cited by" articles


    1. Bodet C, Chandad F, Grenier D. Pathogenic potential of Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, the red bacterial complex associated with periodontitis. Pathologie Biologie. 2007;55(3-4):154–162. - PubMed
    1. Yilmaz Ö. The chronicles of Porphyromonas gingivalise: the microbium, the human oral epithelium and their interplay. Microbiology. 2008;154(10):2897–2903. - PMC - PubMed
    1. Kinane DF, Galicia JC, Gorr S-U, Stathopoulou PG, Benakanakere M. P. gingivalis interactions with epithelial cells. Frontiers in Bioscience. 2008;13(3):966–984. - PubMed
    1. Bostanci N, Belibasakis GN. Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen. FEMS Microbiology Letters. 2012;333(1):1–9. - PubMed
    1. Bélanger M, Rodrigues PH, Dunn WA, Jr., Progulske-Fox A. Autophagy: a highway for Porphyromonas gingivalis in endothelial cells. Autophagy. 2006;2(3):165–170. - PubMed

Publication types

MeSH terms

LinkOut - more resources