A novel phosphorus repletion strategy in a patient with duodenal perforation

Nutr Clin Pract. 2014 Jun;29(3):402-5. doi: 10.1177/0884533614529997. Epub 2014 Apr 17.

Abstract

We describe a case in which a patient receiving parenteral nutrition (PN) developed hypophosphatemia. Due to lack of availability of parenteral phosphate supplements, we chose to restore phosphate using diluted hypertonic sodium phosphate enemas. Due to the recent shortages of parenteral minerals and vitamins, such an alternate means of repletion is of increasing importance. Diluted hypertonic sodium phosphate enemas are inexpensive, easy to administer, and effective since phosphate is readily absorbed across the rectal mucosa. We hope that through this type of repletion, life-threatening hypophosphatemia among patients receiving PN can be avoided.

Keywords: GI access; adult; drug shortage; duodenum; enema; enteral access; fluids-electrolytes/acid-base; life cycle; minerals/trace elements; nutrition; parenteral formulas/compounding; parenteral nutrition; phosphates; phosphorus.

Publication types

  • Case Reports

MeSH terms

  • Dietary Supplements
  • Humans
  • Hypophosphatemia / drug therapy
  • Hypophosphatemia / etiology
  • Intestinal Perforation / blood*
  • Male
  • Micronutrients / administration & dosage
  • Middle Aged
  • Parenteral Nutrition / adverse effects
  • Phosphates / administration & dosage
  • Phosphorus / blood*

Substances

  • Micronutrients
  • Phosphates
  • Phosphorus