Treatment strategies in mastocytosis

Immunol Allergy Clin North Am. 2014 May;34(2):433-47. doi: 10.1016/j.iac.2014.01.012. Epub 2014 Mar 13.

Abstract

Treatment recommendations for mastocytosis are based mostly on expert opinion rather than evidence obtained from controlled clinical trials. In this article, treatment options for mastocytosis are presented, with a focus on the control of mediator-related symptoms in patients with indolent disease.

Keywords: Anti-IgE; Antihistamine; Antimediator therapy; Mastocytosis; Mediator-related symptoms; Platelet-activating factor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / genetics
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / immunology
  • Antibodies, Anti-Idiotypic / therapeutic use*
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Bone and Bones / drug effects
  • Bone and Bones / immunology
  • Bone and Bones / pathology
  • Central Nervous System / drug effects
  • Central Nervous System / immunology
  • Central Nervous System / pathology
  • Dasatinib
  • Gastrointestinal Tract / drug effects
  • Gastrointestinal Tract / immunology
  • Gastrointestinal Tract / pathology
  • Gene Expression
  • Histamine Antagonists / therapeutic use*
  • Humans
  • Mast Cells / drug effects*
  • Mast Cells / immunology
  • Mast Cells / pathology
  • Mastocytosis / drug therapy*
  • Mastocytosis / genetics
  • Mastocytosis / immunology
  • Mastocytosis / pathology
  • Omalizumab
  • Protein Kinase Inhibitors / therapeutic use*
  • Proto-Oncogene Proteins c-kit / antagonists & inhibitors
  • Proto-Oncogene Proteins c-kit / genetics
  • Proto-Oncogene Proteins c-kit / immunology
  • Pyrimidines / therapeutic use
  • Skin / drug effects
  • Skin / immunology
  • Skin / pathology
  • Thiazoles / therapeutic use

Substances

  • Antibodies, Anti-Idiotypic
  • Antibodies, Monoclonal, Humanized
  • Histamine Antagonists
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Thiazoles
  • anti-IgE antibodies
  • Omalizumab
  • Proto-Oncogene Proteins c-kit
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • PLA2G7 protein, human
  • nilotinib
  • Dasatinib