Introduction: We investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case-control study (n=2753) from Sweden.
Materials and methods: 39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression.
Results: Only rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n=7181).
Conclusions: It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.
Keywords: ABO; ANRIL; Coronary artery disease; Genetics; Venous thromboembolism.
Copyright © 2014 Elsevier Ltd. All rights reserved.