Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism

Thromb Res. 2014 Aug;134(2):426-32. doi: 10.1016/j.thromres.2014.03.054. Epub 2014 Apr 4.


Introduction: We investigated whether genetic variations robustly associated with coronary artery disease are also associated with risk of venous thromboembolism in a well-defined, female case-control study (n=2753) from Sweden.

Materials and methods: 39 single nucleotide polymorphisms in 32 loci associated with coronary artery disease in genome-wide association studies were identified in a literature search and genotyped in the ThromboEmbolism Hormone Study (TEHS). Association with venous thromboembolism was assessed by logistic regression.

Results: Only rs579459 in the ABO locus demonstrated a significant association with VTE. A tentative association between ANRIL and VTE in the discovery analysis failed to replicate in a meta-analysis of 4 independent cohorts (total n=7181).

Conclusions: It appears that only the ABO locus is a shared risk factor for coronary artery disease and VTE.

Keywords: ABO; ANRIL; Coronary artery disease; Genetics; Venous thromboembolism.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ABO Blood-Group System / genetics
  • Adolescent
  • Adult
  • Case-Control Studies
  • Coronary Artery Disease / genetics*
  • Female
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genome-Wide Association Study
  • Humans
  • Logistic Models
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • RNA, Long Noncoding / genetics
  • Risk Factors
  • Venous Thromboembolism / genetics*
  • Young Adult


  • ABO Blood-Group System
  • CDKN2B antisense RNA, human
  • RNA, Long Noncoding