Inhalation of coriander volatile oil increased anxiolytic-antidepressant-like behaviors and decreased oxidative status in beta-amyloid (1-42) rat model of Alzheimer's disease

Physiol Behav. 2014 May 28:131:68-74. doi: 10.1016/j.physbeh.2014.04.021. Epub 2014 Apr 18.


The present study analyzed the possible anxiolytic, antidepressant and antioxidant proprieties of inhaled coriander volatile oil extracted from Coriandrum sativum var. microcarpum in beta-amyloid (1-42) rat model of Alzheimer's disease. The anxiolytic- and antidepressant-like effects of inhaled coriander volatile oil were studied by means of in vivo (elevated plus-maze and forced swimming tests) approaches. Also, the antioxidant activity in the hippocampus was assessed using catalase specific activity and the total content of the reduced glutathione. The beta-amyloid (1-42)-treated rats exhibited the following: decrease of the locomotor activity, the percentage of the time spent and the number of entries in the open arm within elevated plus-maze test and decrease of swimming and immobility times within forced swimming test. Exposure to coriander volatile oil significantly improved these parameters, suggesting anxiolytic- and antidepressant-like effects. Moreover, coriander volatile oil decreased catalase activity and increased glutathione level in the hippocampus. Our results suggest that multiple exposures to coriander volatile oil can be useful as a mean to counteract anxiety, depression and oxidative stress in Alzheimer's disease conditions.

Keywords: Anxiety; Beta-amyloid (1–42); Coriander volatile oil; Depression; Oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / physiopathology
  • Amyloid beta-Peptides
  • Animals
  • Anti-Anxiety Agents / therapeutic use
  • Antidepressive Agents / therapeutic use
  • Coriandrum*
  • Disease Models, Animal
  • Exploratory Behavior / drug effects
  • Exploratory Behavior / physiology
  • Glutathione / metabolism
  • Hippocampus / drug effects
  • Hippocampus / physiopathology
  • Male
  • Maze Learning / drug effects
  • Motor Activity / drug effects
  • Motor Activity / physiology
  • Neuropsychological Tests
  • Oils, Volatile / therapeutic use*
  • Oxidative Stress / drug effects*
  • Oxidative Stress / physiology
  • Peptide Fragments
  • Phytotherapy*
  • Plaque, Amyloid / drug therapy
  • Plaque, Amyloid / physiopathology
  • Psychotropic Drugs / therapeutic use*
  • Rats, Wistar


  • Amyloid beta-Peptides
  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Oils, Volatile
  • Peptide Fragments
  • Psychotropic Drugs
  • amyloid beta-protein (1-42)
  • Glutathione