Thrombosis, platelets, microparticles and PAH: more than a clot

Drug Discov Today. 2014 Aug;19(8):1230-5. doi: 10.1016/j.drudis.2014.04.001. Epub 2014 Apr 18.


Pulmonary arterial hypertension (PAH) is a progressive disease that involves pathological remodeling, vasoconstriction and thrombosis. Alterations in hemostasis, coagulation and platelet activation are consistently observed in PAH patients. Microparticles derived from platelets, inflammatory cells and the endothelium are an increasingly well-recognized signal in a variety of cardiovascular diseases, including PAH. This review will focus on the roles of coagulation, thrombosis, platelet activation and microparticles in the pathology and progression of PAH.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Coagulation / physiology
  • Blood Platelets / pathology*
  • Cell-Derived Microparticles / pathology*
  • Humans
  • Hypertension, Pulmonary / pathology*
  • Platelet Activation / physiology
  • Thrombosis / pathology*