The age and genomic integrity of neurons after cortical stroke in humans

Nat Neurosci. 2014 Jun;17(6):801-3. doi: 10.1038/nn.3706. Epub 2014 Apr 20.


It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cellular Senescence / physiology*
  • DNA Fragmentation*
  • DNA Repair / physiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neocortex / pathology*
  • Neocortex / physiology
  • Neurons / pathology*
  • Neurons / physiology
  • Stroke / genetics*
  • Stroke / pathology*

Associated data

  • GEO/GSE56267
  • SRA/SRP040676