Biosynthesis and characterization of Acalypha indica mediated copper oxide nanoparticles and evaluation of its antimicrobial and anticancer activity

Spectrochim Acta A Mol Biomol Spectrosc. 2014 Aug 14:129:255-8. doi: 10.1016/j.saa.2014.03.027. Epub 2014 Mar 28.

Abstract

Copper oxide nanoparticles were synthesized by biological method using aqueous extract of Acalypha indica leaf and characterized by UV-visible spectroscopy, XRD, FT-IR, SEM TEM and EDX analysis. The synthesised particles were highly stable, spherical and particle size was in the range of 26-30 nm. The antimicrobial activity of A.indica mediated copper oxide nanoparticles was tested against selected pathogens. Copper oxide nanoparticles showed efficient antibacterial and antifungal effect against Escherichia coli, Pseudomonas fluorescens and Candida albicans. The cytotoxicity activity of A.indica mediated copper nanoparticles was evaluated by MTT assay against MCF-7 breast cancer cell lines and confirmed that copper oxide nanoparticles have cytotoxicity activity.

Keywords: Acalypha indica; Antimicrobial; Biological method; Copper oxide nanoparticles; Cytotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acalypha / chemistry*
  • Anti-Infective Agents / chemical synthesis
  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / pharmacology
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Bacteria / drug effects
  • Bacterial Infections / drug therapy
  • Breast Neoplasms / drug therapy
  • Candida albicans / drug effects
  • Candidiasis / drug therapy
  • Cell Line, Tumor
  • Copper / chemistry*
  • Copper / pharmacology
  • Female
  • Green Chemistry Technology / methods
  • Humans
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Plant Extracts / chemistry

Substances

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Plant Extracts
  • Copper
  • cuprous oxide