Treatment of gastroesophageal reflux disease: two new oral formulations dexlansoprazole MR and esomezol (esomeprazole strontium)

Expert Opin Pharmacother. 2014 Jun;15(9):1215-22. doi: 10.1517/14656566.2014.911841. Epub 2014 Apr 21.


Introduction: The prevalence of gastroesophageal reflux disease continues to increase with the aging population and the obesity epidemic. Therapeutic failures can have significant detrimental effects in patients. Recently, dexlansoprazole MR and esomeprazole strontium were introduced to the class of proton pump inhibitors (PPIs).

Areas covered: This article will review the pharmacodynamics and pharmacokinetics of dexlansoprazole MR and esomeprazole strontium. Using the keywords 'dexlansoprazole MR' and 'esomeprazole strontium' in the search engines of PubMed, Cochrane Reviews and Google, we were able to identify peer-reviewed publications, abstracts and presentations at national society educations meetings and present a balanced view of the available data.

Expert opinion: Dexlansoprazole MR and esomeprazole strontium offer an innovative delivery mechanism compared to conventional PPIs. Further trials are necessary in order to establish superiority.

Keywords: dexlansoprazole MR; esomeprazole strontium; gastroesophageal reflux disease; proton pump inhibitors.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Animals
  • Clinical Trials as Topic
  • Dexlansoprazole / administration & dosage*
  • Dexlansoprazole / pharmacokinetics
  • Drug Evaluation, Preclinical
  • Esomeprazole / administration & dosage*
  • Esomeprazole / pharmacokinetics
  • Gastroesophageal Reflux / drug therapy*
  • Humans
  • Proton Pump Inhibitors / administration & dosage*
  • Proton Pump Inhibitors / pharmacokinetics
  • Treatment Outcome


  • Proton Pump Inhibitors
  • Esomeprazole
  • Dexlansoprazole