Innovative personalized medicine in gastric cancer: time to move forward

Clin Genet. 2014 Jul;86(1):37-43. doi: 10.1111/cge.12408. Epub 2014 May 10.

Abstract

Globally, gastric cancer (GC) is the second leading cancer cause of death. To date, only one targeted therapy trial generated positive survival outcomes in a selected population among many targeted therapy trials. This trial showed the addition of trastuzumab to fluoropyrimidine/platinum chemotherapy as first-line chemotherapy for human epidermal growth factor receptor 2 (HER2)-positive GC that resulted in an overall survival (OS) benefit. The increasing use of next generation sequencing approach to genomically profile GC patients allows the identification of many more GC patients who could benefit from specific targeted agents. Here we provide a comprehensive review of targeted therapy trials in GC and discuss future potential actionable driver mutations in GC.

Keywords: actionable mutations; chemotherapy; gastric cancer; molecularly targeted agents; personalized medicine.

Publication types

  • Review

MeSH terms

  • Clinical Trials as Topic
  • ErbB Receptors / genetics*
  • ErbB Receptors / metabolism
  • Humans
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Precision Medicine / methods*
  • Precision Medicine / trends
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-met / genetics*
  • Proto-Oncogene Proteins c-met / metabolism
  • Proto-Oncogene Proteins p21(ras)
  • Receptor, ErbB-2 / genetics*
  • Receptor, ErbB-2 / metabolism
  • Receptor, Fibroblast Growth Factor, Type 2 / genetics
  • Receptor, Fibroblast Growth Factor, Type 2 / metabolism
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / genetics*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Vascular Endothelial Growth Factor A / metabolism
  • ras Proteins / genetics
  • ras Proteins / metabolism

Substances

  • ARID1A protein, human
  • KRAS protein, human
  • Nuclear Proteins
  • Proto-Oncogene Proteins
  • Transcription Factors
  • Vascular Endothelial Growth Factor A
  • EGFR protein, human
  • ERBB2 protein, human
  • ErbB Receptors
  • FGFR2 protein, human
  • MET protein, human
  • Proto-Oncogene Proteins c-met
  • Receptor, ErbB-2
  • Receptor, Fibroblast Growth Factor, Type 2
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins