Use of statin during hospitalization improves the outcome after intracerebral hemorrhage

CNS Neurosci Ther. 2014 Jun;20(6):548-55. doi: 10.1111/cns.12274. Epub 2014 Apr 21.


Aims: To examine the relationship between statin use in Chinese patients with intracerebral hemorrhage (ICH) during their hospitalization and the outcomes.

Methods: Data were collected from the China National Stroke Registry. Good functional outcome was defined by a modified Rankin Scale score between 0-2. Functional outcome and rate of mortality at 3 months and 1 year were compared between ICH patients on statin and those without it during their hospitalization. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated using the multivariable logistic regression model adjusted for baseline risk factors.

Results: Among 3218 consecutive ICH patients from 2007 to 2008, 220 (6.8%) were on statin during their hospitalization. Compared with those without statin, patients on statin were younger, had more stroke risk factors but lower stroke severity. ICH patients on statin had better functional outcome at 3 months (OR 2.24, 95% CI 1.49-3.36) and at 1 year (OR 2.04, 95% CI 1.37-3.06). They also had lower rate of mortality at 3 months (OR 0.44, 95% CI 0.22-0.87) and 1 year (OR 0.49, 95% CI 0.27-0.86).

Conclusions: In-hospital statin use in ICH patients is associated with better functional outcome and lower mortality at 3 months and 1 year.

Keywords: Hemorrhagic stroke; Intracerebral hemorrhage; Outcome; Statin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cerebral Hemorrhage / therapy*
  • China
  • Female
  • Follow-Up Studies
  • Hospitalization*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Male
  • Middle Aged
  • Outcome Assessment, Health Care
  • Registries
  • Retrospective Studies
  • Risk Factors
  • Severity of Illness Index
  • Statistics, Nonparametric
  • Treatment Outcome*


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors