Peritoneal dialysis-related peritonitis: towards improving evidence, practices, and outcomes

Am J Kidney Dis. 2014 Aug;64(2):278-89. doi: 10.1053/j.ajkd.2014.02.025. Epub 2014 Apr 18.


Peritonitis is a common serious complication of peritoneal dialysis that results in considerable morbidity, mortality, and health care costs. It also significantly limits the use of this important dialysis modality. Despite its importance as a patient safety issue, peritonitis practices and outcomes vary markedly and unacceptably among different centers, regions, and countries. This article reviews peritonitis risk factors, diagnosis, treatment, and prevention, particularly focusing on potential drivers of variable practices and outcomes, controversial or unresolved areas, and promising avenues warranting further research. Potential strategies for augmenting the existing limited evidence base and reducing the gap between evidence-based best practice and actual practice also are discussed.

Keywords: Antibiotics; bacteria; fungi; microbiology; outcomes; peritoneal dialysis; peritonitis; practice variation; prevention; quality improvement; risk factors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Peritoneal Dialysis / adverse effects*
  • Peritoneal Dialysis / trends
  • Peritonitis / diagnosis
  • Peritonitis / etiology*
  • Peritonitis / prevention & control*
  • Risk Factors
  • Treatment Outcome