Studying aging in Drosophila

Methods. 2014 Jun 15;68(1):129-33. doi: 10.1016/j.ymeth.2014.04.008. Epub 2014 Apr 18.

Abstract

Drosophila melanogaster represents one of the most important genetically accessible model organisms for aging research. Studies in flies have identified single gene mutations that influence lifespan and have characterized endocrine signaling interactions that control homeostasis systemically. Recent studies have focused on the effects of aging on specific tissues and physiological processes, providing a comprehensive picture of age-related tissue dysfunction and the loss of systemic homeostasis. Here we review methodological aspects of this work and highlight technical considerations when using Drosophila to study aging and age-related diseases.

Keywords: Aging; Degeneration; Drosophila; Homeostasis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aging / genetics*
  • Aging / pathology
  • Animals
  • Developmental Biology / methods*
  • Drosophila / genetics
  • Drosophila / growth & development*
  • Homeostasis
  • Models, Animal