Colorectal cancer: serrated polyposis--should we screen first-degree relatives?

Nat Rev Gastroenterol Hepatol. 2014 Jun;11(6):333-4. doi: 10.1038/nrgastro.2014.61. Epub 2014 Apr 22.


Serrated polyposis syndrome (SPS) is a condition characterized by multiple and/or proximal serrated polyps in the colorectum. Several features of SPS suggest there is an underlying genetic disorder that is yet to be identified. A new study provides insights on the diagnostic yield of screening colonoscopy in first-degree relatives of patients with SPS.

MeSH terms

  • Colonic Polyps / genetics*
  • Colonic Polyps / pathology
  • Colonoscopy
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology
  • Genetic Predisposition to Disease
  • Humans
  • Intestinal Polyposis / diagnosis
  • Intestinal Polyposis / pathology
  • Prospective Studies