Guideline for the prevention and treatment of anticipatory nausea and vomiting due to chemotherapy in pediatric cancer patients

Pediatr Blood Cancer. 2014 Aug;61(8):1506-12. doi: 10.1002/pbc.25063. Epub 2014 Apr 17.


This guideline provides an approach to the prevention and treatment of anticipatory chemotherapy-induced nausea and vomiting (CINV) in children. It was developed by an international, inter-professional panel using AGREE II methods and is based on systematic literature reviews. Evidence-based recommendations for pharmacological and non-pharmacological interventions to prevent and treat anticipatory CINV in children receiving antineoplastic agents are provided. Gaps in the evidence used to support the recommendations are identified. The contribution of this guideline to anticipatory CINV control in children requires prospective evaluation.

Keywords: antineoplastic agents; nausea; supportive care; vomiting.

Publication types

  • Practice Guideline
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Child
  • Child, Preschool
  • Evidence-Based Medicine
  • Female
  • Humans
  • Infant
  • Male
  • Nausea / chemically induced
  • Nausea / prevention & control*
  • Neoplasms / drug therapy*
  • Vomiting / chemically induced
  • Vomiting / prevention & control*


  • Antineoplastic Agents