Effects of THA on ionic currents in myelinated axons of Xenopus laevis

Eur J Pharmacol. 1989 May 30;164(3):599-602. doi: 10.1016/0014-2999(89)90272-0.

Abstract

In voltage-clamp experiments with the myelinated nerve fibre of Xenopus laevis, 9-amino-1,2,3,4-tetrahydroacridine (THA) decreased both Na+ and K+ currents and shifted the steady state inactivation potential curve in a negative direction. The effects may be described as (a) a decrease of the permeability constant PNa, (b) a modified potential dependence of the inactivating system and (c) a decrease of PK. The Na+ system was affected more than the K+ system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoacridines / pharmacology*
  • Animals
  • Axons / drug effects
  • Axons / metabolism*
  • Humans
  • In Vitro Techniques
  • Ion Channels / drug effects*
  • Myelin Sheath / physiology*
  • Potassium Chloride / pharmacology
  • Sciatic Nerve / drug effects
  • Sciatic Nerve / physiology
  • Tacrine / pharmacology*
  • Xenopus laevis

Substances

  • Aminoacridines
  • Ion Channels
  • Tacrine
  • Potassium Chloride