Regulation of miR-23b expression and its dual role on ROS production and tumour development

Cancer Lett. 2014 Jul 28;349(2):107-13. doi: 10.1016/j.canlet.2014.04.012. Epub 2014 Apr 19.

Abstract

Among the wide family of microRNAs, microRNA 23b (miR-23b) intriguingly assumes opposite roles on regulation of reactive oxygen species (ROS) and on the development of human cancers. In this review we describe novel findings concerning the molecular events involved in miR-23b gene activation or repression and in both ROS regulation and tumour development. In particular, we define the molecular targets of miR-23b that determine its function as either a tumour suppressor or oncomir in different cell types. Finally, we analyze the involvement of miR-23b in cancer cell metabolism, including autophagy, and in biomarker signatures of microRNAs allowing a prognostic and therapeutic evaluation in various human cancers.

Keywords: Cancer; MicroRNAs; Reactive oxygen species; Transcriptional regulation; miR-23b.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs / biosynthesis*
  • MicroRNAs / genetics
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Reactive Oxygen Species / metabolism*

Substances

  • MIRN23a microRNA, human
  • MicroRNAs
  • Reactive Oxygen Species