Influence of hormonal parameters, bone mineral density and bone turnover on fracture risk in healthy male adolescents: a case control study

J Pediatr Endocrinol Metab. 2014 Jul;27(7-8):685-92. doi: 10.1515/jpem-2013-0407.


Objective: The aim of this study was to assess possible associations between potential risk factors for fractures and their occurrence in otherwise healthy Greek male adolescents.

Subjects: A total of 63 male adolescents participated in the study, 21 males with a history of at least one fracture and 42 healthy male controls.

Methods: Each participant was assessed for physical and pubertal status, hormonal profile, bone mineral density, bone turnover indices, and dietary habits.

Results: The lower bone mineral density-z scores and increasing testosterone and serum collagen type 1 cross-linked C-telopeptide levels were related to fracture risk, whereas increased insulin-like growth factor-1, soluble receptor activator of nuclear factor kappa-B (factor-κB) ligand, and soluble receptor activator of nuclear factors-κB ligand/osteoprotegerin levels were protective for fractures.

Conclusions: The findings indicate a potential 'added value' of hormonal parameters and bone markers to bone mineral density for evaluating fracture risk in healthy male adolescents.

MeSH terms

  • Adolescent
  • Bone Density*
  • Bone and Bones / metabolism*
  • Case-Control Studies
  • Collagen Type I / metabolism
  • Fractures, Bone / etiology*
  • Humans
  • Male
  • Peptides / metabolism
  • Risk


  • Collagen Type I
  • Peptides
  • collagen type I trimeric cross-linked peptide