Gastroprotective activity of essential oils from turmeric and ginger

J Basic Clin Physiol Pharmacol. 2015 Jan;26(1):95-103. doi: 10.1515/jbcpp-2013-0165.


Background: Turmeric (Curcuma longa) and ginger (Zingiber officianale) are widely used in Asian countries as traditional medicine and food ingredients. In the present study, we have evaluated the gastroprotective activity of turmeric essential oil (TEO) and ginger essential oil (GEO) in rats.

Methods: Turmeric and ginger were evaluated for their antiulcer activity against ethanol-induced ulcers in male Wistar rats at different doses: 100, 500 and 1000 mg/kg body weight. Ethanol was used to induce gastric ulcer in Wistar rats. Parameters such as ulcer index, histopathology and levels of antioxidant enzymes such as glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase and glutathione (GSH) levels were measured to assess the degree of protection produced by the essential oils.

Results: TEO and GEO inhibited ulcer by 84.7% and 85.1%, respectively, as seen from the ulcer index. Reduced antioxidant enzymes such as GPx, SOD, catalase and GSH produced by alcohol administration were significantly (p<0.001) increased by simultaneous administration of TEO and GEO. Histopathological examination showed that ethanol-induced lesions such as necrosis, erosion and hemorrhage of the stomach wall were significantly reduced after oral administration of essential oils.

Conclusions: RESULTS suggest that TEO and GEO could reduce the gastric ulcer in rat stomach as seen from the ulcer index and histopathology of the stomach. Moreover, oxidative stress produced by ethanol was found to be significantly reduced by TEO and GEO.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Ulcer Agents / administration & dosage
  • Anti-Ulcer Agents / isolation & purification
  • Anti-Ulcer Agents / pharmacology*
  • Antioxidants / metabolism
  • Curcuma / chemistry*
  • Dose-Response Relationship, Drug
  • Ethanol / toxicity
  • Ginger / chemistry*
  • Male
  • Oils, Volatile / administration & dosage
  • Oils, Volatile / isolation & purification
  • Oils, Volatile / pharmacology*
  • Oxidative Stress / drug effects
  • Rats
  • Rats, Wistar
  • Stomach Ulcer / drug therapy
  • Stomach Ulcer / pathology


  • Anti-Ulcer Agents
  • Antioxidants
  • Oils, Volatile
  • Ethanol