The TRPV4 channel

Handb Exp Pharmacol. 2014;222:293-319. doi: 10.1007/978-3-642-54215-2_12.


The widely distributed TRPV4 cationic channel participates in the transduction of both physical (osmotic, mechanical, and heat) and chemical (endogenous, plant-derived, and synthetic ligands) stimuli. In this chapter we will review TRPV4 expression, biophysics, structure, regulation, and interacting partners as well as physiological and pathological insights obtained in TRPV4 animal models and human genetic studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Membrane Potentials
  • Mice, Knockout
  • Protein Conformation
  • Signal Transduction
  • Structure-Activity Relationship
  • TRPV Cation Channels / chemistry
  • TRPV Cation Channels / deficiency
  • TRPV Cation Channels / genetics
  • TRPV Cation Channels / metabolism*


  • TRPV Cation Channels
  • TRPV4 protein, human
  • Trpv4 protein, mouse